Difference between revisions of "Spo0A"
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* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' receives phosphorylation from [[Spo0B]], dephosphorylation by [[Spo0E]] | + | * '''Modification:''' receives phosphorylation from [[Spo0B]], dephosphorylation by [[Spo0E]], direct phosphorylation by [[KinC]] upon potassium leakage {{PubMed|19114652}} |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| Line 78: | Line 78: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[Spo0A]]-[[Spo0E]], [[Spo0A]]-[[SigA]] | + | * '''Interactions:''' [[KinC]]-[[Spo0A]] {{PubMed|19114652}}, [[Spo0A]]-[[Spo0E]], [[Spo0A]]-[[SigA]] |
* '''Localization:''' | * '''Localization:''' | ||
| Line 132: | Line 132: | ||
=References= | =References= | ||
| − | <pubmed>19528067, 19581368 , 8730857,2106683,3157992, 11254139,1569009, 12067336,10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382,9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 14651647,1537790,9658000,8509330,14762002,1846779,2981817,15687200, 9477965,8600030, 18840696, 1391039, 14679239, 14976210, 19207565 11679073 </pubmed> | + | <pubmed>19528067, 19581368 , 8730857,2106683,3157992, 11254139,1569009, 12067336,10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 19114652 14651647,1537790,9658000, 8509330,14762002, 1846779, 2981817, 15687200, 9477965,8600030, 18840696, 1391039, 14679239, 14976210, 19207565 11679073 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:02, 30 November 2009
- Description: phosphorelay regulator, initiation of sporulation
| Gene name | spo0A |
| Synonyms | spo0C, spo0G, spoIIL, sof-1 |
| Essential | no |
| Product | phosphorelay response regulator |
| Function | initiation of sporulation |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Ammonium/ glutamate, Central C-metabolism, Sugar catabolism, Stress, tRNA charging | |
| MW, pI | 29 kDa, 5.989 |
| Gene length, protein length | 801 bp, 267 aa |
| Immediate neighbours | yqiG, spoIVB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU24220
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Genes controlled by Spo0A
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
- UniProt: P06534
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: spo0A PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Tony Wilkinson, York University, U.K. homepage
- Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage
- Charles Moran, Emory University, NC, USA homepage
Your additional remarks
References
