Difference between revisions of "FlgM"
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 264 bp, 88 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 264 bp, 88 aa | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[flgN]]'', ''[[yvyF]]'' |
|- | |- | ||
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35430 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35430 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35430 DNA_with_flanks] | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35430 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35430 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35430 DNA_with_flanks] | ||
| Line 81: | Line 81: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 108: | Line 108: | ||
=Expression and regulation= | =Expression and regulation= | ||
* '''Operon:''' | * '''Operon:''' | ||
| − | ** ''[[comFA]]-[[comFB]]-[[comFC]]-[[yvyF]]-[[flgM]]-[[ | + | ** ''[[comFA]]-[[comFB]]-[[comFC]]-[[yvyF]]-[[flgM]]-[[flgN]]-[[flgK]]-[[flgL]]'' {{PubMed|8412657}} |
| − | ** ''[[yvyF]]-[[flgM]]-[[ | + | ** ''[[yvyF]]-[[flgM]]-[[flgN]]-[[flgK]]-[[flgL]]'' {{PubMed|8045879}} |
| − | ** ''[[flgM]]-[[ | + | ** ''[[flgM]]-[[flgN]]-[[flgK]]-[[flgL]]'' {{PubMed|21736639}} |
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=flgM_3640285_3640551_-1 flgM] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=flgM_3640285_3640551_-1 flgM] {{PubMed|22383849}} | ||
Revision as of 14:41, 8 April 2014
- Description: anti-SigD, regulation of flagellin, motility, and chemotaxis
| Gene name | flgM |
| Synonyms | |
| Essential | no |
| Product | anti-SigD |
| Function | control of SigD activity |
| Gene expression levels in SubtiExpress: flgM | |
| Interactions involving this protein in SubtInteract: FlgM | |
| MW, pI | 9 kDa, 9.918 |
| Gene length, protein length | 264 bp, 88 aa |
| Immediate neighbours | flgN, yvyF |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
sigma factors and their control, motility and chemotaxis
This gene is a member of the following regulons
ComK regulon, DegU regulon, ScoC regulon, SigD regulon
The gene
Basic information
- Locus tag: BSU35430
Phenotypes of a mutant
Database entries
- BsubCyc: BSU35430
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: flgM family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
Database entries
- BsubCyc: BSU35430
- Structure:
- UniProt: P39809
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Wai Kit Ma, Rachel Hendrix, Claire Stewart, Eric V Campbell, Mitchell Lavarias, Kolyn Morris, Shauna Nichol, Matthew J Gage
FlgM proteins from different bacteria exhibit different structural characteristics.
Biochim Biophys Acta: 2013, 1834(4);808-16
[PubMed:23352839]
[WorldCat.org]
[DOI]
(P p)
Loralyn M Cozy, Daniel B Kearns
Gene position in a long operon governs motility development in Bacillus subtilis.
Mol Microbiol: 2010, 76(2);273-85
[PubMed:20233303]
[WorldCat.org]
[DOI]
(I p)
Prashant Kodgire, K Krishnamurthy Rao
A dual mode of regulation of flgM by ScoC in Bacillus subtilis.
Can J Microbiol: 2009, 55(8);983-9
[PubMed:19898538]
[WorldCat.org]
[DOI]
(I p)
M G Bertero, B Gonzales, C Tarricone, F Ceciliani, A Galizzi
Overproduction and characterization of the Bacillus subtilis anti-sigma factor FlgM.
J Biol Chem: 1999, 274(17);12103-7
[PubMed:10207036]
[WorldCat.org]
[DOI]
(P p)
K Fredrick, J D Helmann
FlgM is a primary regulator of sigmaD activity, and its absence restores motility to a sinR mutant.
J Bacteriol: 1996, 178(23);7010-3
[PubMed:8955328]
[WorldCat.org]
[DOI]
(P p)
T Caramori, D Barilla, C Nessi, L Sacchi, A Galizzi
Role of FlgM in sigma D-dependent gene expression in Bacillus subtilis.
J Bacteriol: 1996, 178(11);3113-8
[PubMed:8655488]
[WorldCat.org]
[DOI]
(P p)
D B Mirel, P Lauer, M J Chamberlin
Identification of flagellar synthesis regulatory and structural genes in a sigma D-dependent operon of Bacillus subtilis.
J Bacteriol: 1994, 176(15);4492-500
[PubMed:8045879]
[WorldCat.org]
[DOI]
(P p)
J A Londoño-Vallejo, D Dubnau
comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.
Mol Microbiol: 1993, 9(1);119-31
[PubMed:8412657]
[WorldCat.org]
[DOI]
(P p)
