HrcA

• Description: transcriptional repressor of class I heat-shock genes
  
  

Gene name	hrcA
Synonyms	yqxE, yqeS
Essential	no
Product	transcriptional repressor
Function	regulation of chaperone gene expression
Gene expression levels in SubtiExpress: hrcA
Interactions involving this protein in SubtInteract: HrcA
Metabolic function and regulation of this protein in SubtiPathways: hrcA
MW, pI	38 kDa, 6.079
Gene length, protein length	1029 bp, 343 aa
Immediate neighbours	grpE, hemN
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, heat shock proteins

This gene is a member of the following regulons

HrcA regulon

The HrcA regulon:

• hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV, groES-groEL

The gene

Basic information

• Locus tag: BSU25490

Database entries

• BsubCyc: BSU25490

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription repressor of the * hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV and groES-groEL operons (at low/ normal temperatures)

• Protein family: hrcA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on arginine residues PubMed

• Cofactors: GroEL acts as co-repressor

• Effectors of protein activity:

• Interactions: GroEL-HrcA

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU25490

• Structure:

• UniProt: P25499

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV PubMed

• Expression browser: hrcA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by heat shock (HrcA) PubMed

• Regulatory mechanism:
  • HrcA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage

Thomas Wiegert, University of Bayreuth, Germany Homepage