Difference between revisions of "MecA"
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| − | * '''Description:''' | + | * '''Description:''' buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets [[ComK]] to [[ClpC]]-[[ClpP]] degradation machine (in log Phase), inhibits the transcriptional activity of [[Spo0A]]∼P by direct interaction <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[MecA]]-[[ComK]] | + | * '''Interactions:''' |
| + | ** [[MecA]]-[[ComK]] {{PubMed|10447896}} | ||
| + | ** [[MecA]]-[[ComS]] {{PubMed|10447896}} | ||
| + | ** [[ClpC]]-[[MecA]] {{PubMed|10447896}} | ||
| + | ** [[MecA]]-[[Spo0A]] {{PubMed|21435029}} | ||
* '''Localization:''' | * '''Localization:''' | ||
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<pubmed> 19609260 </pubmed> | <pubmed> 19609260 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>11914365,12028382,8016067,9000055,17560370,19361434,,9890793,2113920,8817496,16525504,12598648,,10447896,8412687,11918817, 10447896, 12028382, 8016067, 10361283, 11703662 9535081 19767395 19801546 8016066 19202088 </pubmed> | + | <pubmed>11914365,12028382,8016067,9000055,17560370,19361434,,9890793,2113920,8817496,16525504,12598648,21435029 ,10447896,8412687,11918817, 10447896, 12028382, 8016067, 10361283, 11703662 9535081 19767395 19801546 8016066 19202088 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:47, 26 March 2011
- Description: buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets ComK to ClpC-ClpP degradation machine (in log Phase), inhibits the transcriptional activity of Spo0A∼P by direct interaction
| Gene name | mecA |
| Synonyms | |
| Essential | no |
| Product | adaptor protein |
| Function | control of ComK degradation, regulation of competence |
| MW, pI | 25 kDa, 4.209 |
| Gene length, protein length | 654 bp, 218 aa |
| Immediate neighbours | yjbE, coiA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
genetic competence, proteolysis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU11520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: mecA family (according to Swiss-Prot)
- Paralogous protein(s): YpbH
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P37958
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP813 (spc), GP814 (aphA3) both available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260]
[WorldCat.org]
[DOI]
(I p)
Original Publications
