Difference between revisions of "SpoIVCB"

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(Extended information on the protein)
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* '''Description:''' sporulation-specific [[sigma factor]] (SigK) (N-terminal half), other part: ''[[spoIIIC]]''
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* '''Description:''' sporulation-specific [[sigma factor]] ([[SigK]]) (N-terminal half), other part: ''[[spoIIIC]]''
 
<br/><br/>
 
<br/><br/>
 
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''[[sigK]]'' (composed of ''[[spoIVCB]]-[[spoIIIC]]'') {{PubMed|2536191}}
  
* '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190}}
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* '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190,2841290}}, [[SigK]] {{PubMed|2841290}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** expressed during sporulation in the mother cell ([[SigE]], [[SigK]], [[GerE]], [[SpoIIID]]) {{PubMed|15699190,2841290,10075739,7966271}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[GerE]]: transcription repression {{PubMed|10075739}}
 +
** [[SpoIIID]]: transcription activation {{PubMed|7966271}}
  
* '''Additional information:''' SigK is activated by processing of membrane-bound pro-SigK by the [[SpoIVFB]] metalloprotease {{PubMed|19805276}}
+
* '''Additional information:'''  
 +
** SigK is activated by processing of membrane-bound pro-SigK by the [[SpoIVFB]] metalloprotease {{PubMed|19805276}}
 +
** ''spoIVCB'' and ''[[spoIIIC]]'' form a composite gene in the mother cell during sporulation by excising the intervening DNA sequence.
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
  
<pubmed>14526016,17720779,1900494,10438769,2492118,16385044,1691789,15383836,2536191,2163341,10931284,1577688,9852018,1942049,7814326,8550479,11959848,9501233,10400595,2115401,7592342,1518043,8226681,9078383,2514119,10611287,14523132, 19805276 </pubmed>
+
<pubmed>14526016,17720779,1900494,10438769,2492118,16385044,1691789,15383836,2536191,2163341,10931284,1577688,9852018,1942049,7814326,8550479,11959848,9501233,10400595,2115401,7592342,1518043,8226681,9078383,2514119,10611287,14523132, 19805276 10075739 7966271 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:57, 24 November 2009



Gene name spoIVCB
Synonyms cisB, sigK
Essential no
Product RNA polymerase sporulation-specific sigma factor
(sigma-K) (N-terminal half)
Function late mother cell-specific gene expression
MW, pI 17 kDa, 8.208
Gene length, protein length 468 bp, 156 aa
Immediate neighbours nucB, spoIVCA
Gene sequence (+200bp) Protein sequence
Caution: The sequence for this gene in SubtiList contains errors
Genetic context
SpoIVCB context.gif
This image was kindly provided by SubtiList





The gene

Basic information

  • Locus tag: BSU25760

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: sigma-70 factor family (according to Swiss-Prot)
  • Paralogous protein(s):

Genes controlled by SigK

gerE, lipC, surC, yabG, yndL, yitB-yitA-yisZ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:
    • SigK is activated by processing of membrane-bound pro-SigK by the SpoIVFB metalloprotease PubMed
    • spoIVCB and spoIIIC form a composite gene in the mother cell during sporulation by excising the intervening DNA sequence.

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References