SigG

• Description: RNA polymerase sporulation forespore-specific (late) sigma factor SigG
  
  

Gene name	sigG
Synonyms	spoIIIG
Essential	no
Product	RNA polymerase sporulation forespore-specific (late) sigma factor SigG
Function	transcription of sporulation genes (late forespore)
MW, pI	29 kDa, 5.496
Gene length, protein length	780 bp, 260 aa
Immediate neighbours	sigE, ylmA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15330

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: sigma-70 factor family (according to Swiss-Prot)

• Paralogous protein(s):

Genes controlled by SigG

dacF-spoIIAA-spoIIAB-sigF, sigG, pbpF, pbpG, spoVAA-spoVAB-spoVAC-spoVAD-spoVAE-spoVAF-lysA, spoVT, sleB-ypeB, sspF, ybaK-cwlD, sspL, yyxA PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: CsfB inhibits SigG activity

• Interactions: CsfB-SigG PubMed, SpoIIAB-SigG

• Localization:

Database entries

• Structure:

• UniProt: P19940

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • spoIIGA-sigE-sigG
  • sigG

• Sigma factor:
  • spoIIGA: SigA
  • sigG: SigF, SigG

• Regulation:
  • spoIIGA: expressed early during sporulation (Spo0A)
  • sigG: expressed during sporulation

• Regulatory mechanism: activated by Spo0A, repression by SinR

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Charles Moran, Emory University, NC, USA homepage