Difference between revisions of "T-box"

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(Genes controlled by T-box elements)
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In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA  of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
 
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA  of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
  
==Genes controlled by T-box elements==
+
==Complete list of genes controlled by T-box elements==
  
 
* Induction by alanine limitation
 
* Induction by alanine limitation

Revision as of 04:30, 28 May 2009

The T-box element is an RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Complete list of genes controlled by T-box elements

  • Induction by alanine limitation
  • Induction by aspartate limitation
  • Induction by histidine limitation
  • Induction by phenyalanine limitation
  • Induction by serine limitation
  • Induction by threonine limitation
  • Induction by tyrosine limitation

Reviews on T-box regulation

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)

T M Henkin, F J Grundy
Sensing metabolic signals with nascent RNA transcripts: the T box and S box riboswitches as paradigms.
Cold Spring Harb Symp Quant Biol: 2006, 71;231-7
[PubMed:17381302] [WorldCat.org] [DOI] (P p)

T M Henkin
tRNA-directed transcription antitermination.
Mol Microbiol: 1994, 13(3);381-7
[PubMed:7527891] [WorldCat.org] [DOI] (P p)

F J Grundy, T M Henkin
tRNA as a positive regulator of transcription antitermination in B. subtilis.
Cell: 1993, 74(3);475-82
[PubMed:8348614] [WorldCat.org] [DOI] (P p)