Biosynthesis/ acquisition of nucleotides

Parent categories	2. Metabolism 2.5. Nucleotide metabolism
Neighbouring categories	2.5.1. Utilization of nucleotides 2.5.2. Biosynthesis/ acquisition of nucleotides 2.5.3. Metabolism of signalling nucleotides 2.5.4. Nucleotide metabolism/ other
Related categories	A-box G-box PurR regulon PyrR regulon
Overview on the categories (Excel file) All genes and their categories (Excel file)

Genes in this functional category

Biosynthesis/ acquisition of purine nucleotides

• adk
• gmk
• guaA
• guaB
• nupG
• nupN
• nupO
• nupP
• nupQ
• pbuG
• pbuX
• prs
• purA
• purB
• purC
• purD
• purE
• purF
• purH
• purK
• purL
• purM
• purN
• purQ
• purR
• purS
• purT
• yabJ
• ykkE

Biosynthesis/ acquisition of purine nucleotides/ based on similarity

• pbuO

Purine salvage and interconversion

• apt
• dck
• deoD
• dgk
• guaC
• guaD
• hprT
• pupG
• xpt

Biosynthesis/ acquisition of pyrimidine nucleotides

• cmk
• prs
• pyrAA
• pyrAB
• pyrB
• pyrC
• pyrD
• pyrE
• pyrF
• pyrG
• pyrH
• pyrK
• pyrP
• pyrR
• tdk
• thyA
• thyB
• tmk
• udk
• upp

Biosynthesis/ acquisition of nucleotides/ other

• nrdE
• nrdEB
• nrdF
• nrdI
• rnr
• yhcR

Biosynthesis/ acquisition of nucleotides/ other/ based on similarity

• yutK
• yxlA

Important publications

Bjarne Hove-Jensen, Kasper R Andersen, Mogens Kilstrup, Jan Martinussen, Robert L Switzer, Martin Willemoës
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.
Microbiol Mol Biol Rev: 2017, 81(1);
[PubMed:28031352] [WorldCat.org] [DOI] (I e)

Jennifer Janina Stepanek, Sina Schäkermann, Michaela Wenzel, Pascal Prochnow, Julia Elisabeth Bandow
Purine biosynthesis is the bottleneck in trimethoprim-treated Bacillus subtilis.
Proteomics Clin Appl: 2016, 10(9-10);1036-1048
[PubMed:27329548] [WorldCat.org] [DOI] (I p)

Hui Zhu, Shao-Mei Yang, Zhao-Min Yuan, Rui Ban
Metabolic and genetic factors affecting the productivity of pyrimidine nucleoside in Bacillus subtilis.
Microb Cell Fact: 2015, 14;54
[PubMed:25890046] [WorldCat.org] [DOI] (I e)

Y Zhang, M Morar, S E Ealick
Structural biology of the purine biosynthetic pathway.
Cell Mol Life Sci: 2008, 65(23);3699-724
[PubMed:18712276] [WorldCat.org] [DOI] (I p)

T J Kappock, S E Ealick, J Stubbe
Modular evolution of the purine biosynthetic pathway.
Curr Opin Chem Biol: 2000, 4(5);567-72
[PubMed:11006546] [WorldCat.org] [DOI] (P p)