Difference between revisions of "ComA"
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' phosphorylated by [[ComP]] on an Asp residue | * '''Modification:''' phosphorylated by [[ComP]] on an Asp residue | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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==Original Publications== | ==Original Publications== | ||
| − | <pubmed>17227471 11133937,2116363,12067344,8387999,19202088, 10094672,8643670,11267663, 15968044 16816200, 10447896,12950917, 20302877 12270822 17581123 16816200 2507523 20208433 22215984</pubmed> | + | <pubmed>17227471 11133937,2116363,12067344,8387999,19202088, 10094672,8643670,11267663, 15968044 16816200, 10447896,12950917, 20302877 12270822 17581123 16816200 2507523 20208433 22215984 24130811 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:37, 6 December 2013
- Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
| Gene name | comA |
| Synonyms | srfB, comAA |
| Essential | no |
| Product | two-component system response regulator |
| Function | regulation of genetic competence and quorum sensing |
| Gene expression levels in SubtiExpress: comA | |
| Interactions involving this protein in SubtInteract: ComA | |
| MW, pI | 23 kDa, 4.759 |
| Gene length, protein length | 642 bp, 214 aa |
| Immediate neighbours | yuxO, comP |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
genetic competence, transcription factors and their control, quorum sensing, phosphoproteins
This gene is a member of the following regulons
The ComA regulon
The gene
Basic information
- Locus tag: BSU31680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ComA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification: phosphorylated by ComP on an Asp residue
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P14204
- KEGG entry: [3]
- E.C. number: 4.4.1.19
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol Rev: 2010, 34(2);134-49
[PubMed:20030732]
[WorldCat.org]
[DOI]
(I p)
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
Original Publications
