Difference between revisions of "BioB"

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Revision as of 14:21, 16 May 2013

  • Description: biotin synthase

Gene name bioB
Synonyms
Essential no
Product biotin synthase)
Function biosynthesis of biotin
Gene expression levels in SubtiExpress: bioB
Metabolic function and regulation of this protein in SubtiPathways:
Biotin
MW, pI 36 kDa, 5.554
Gene length, protein length 1005 bp, 335 aa
Immediate neighbours bioI, bioD
Sequences Protein DNA DNA_with_flanks
Genetic context
BioB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BioB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

BirA regulon

The gene

Basic information

  • Locus tag: BSU30200

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot)
  • Protein family: Biotin synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): contains an iron-sulfur cluster
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

  • Regulation:
    • repressed in the presence of biotin (BirA) PubMed
  • Regulatory mechanism:
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews: PubMed

Original publications