Sandbox

• Achtung: transcriptional activator of the acoA-acoB-acoC-acoL operon
  
  

Gene name	acoR
Synonyms	yfjG, yzcB
Essential	no
Product	transcriptional activator (for SigL-dependent promoter)
Function	regulation of acetoin utilization
Gene expression levels in SubtiExpress: dacA
Interactions involving this protein in SubtInteract: AcoR
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	66 kDa, 7.884
Gene length, protein length	1815 bp, 605 aa
Immediate neighbours	acoL, sspH
Get the [ http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00100 DNA] and protein sequence (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon

The AcoR regulon:

• acoA-acoB-acoC-acoL

The gene

Basic information

• Locus tag: BSU08100

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31551

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acoR-sspH PubMed

• Expression browser: acoR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (3.7-fold) (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1S112 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage