Difference between revisions of "BirA"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | =The [[BirA regulon]]:= | |
| + | * ''[[bioW]]-[[bioA]]-[[bioF]]-[[bioD]]-[[bioB]]-[[bioI]]-[[ytbQ]]'' | ||
=The gene= | =The gene= | ||
Revision as of 17:45, 11 December 2010
- Description: trigger enzyme: transcriptional repressor of the biotin operon / biotin-protein ligase
| Gene name | birA |
| Synonyms | |
| Essential | yes PubMed |
| Product | trigger enzyme: transcriptional repressor/ biotin-protein ligase |
| Function | regulation of biotin synthesis, addition of biotin to proteins |
| MW, pI | 36 kDa, 6.769 |
| Gene length, protein length | 975 bp, 325 aa |
| Immediate neighbours | panB, cca |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis of lipids, biosynthesis of cofactors, transcription factors and their control, trigger enzyme, essential genes
This gene is a member of the following regulons
The BirA regulon:
The gene
Basic information
- Locus tag: BSU22440
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P42975
- KEGG entry: [2]
- E.C. number: 6.3.4.15
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Operon and expression
Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541]
[WorldCat.org]
[DOI]
(I p)
