sul
168
dihydropteroate synthase
locus
BSU_00770
Molecular weight
30.85 kDa
pI
5.36
function
biosynthesis of folate
product
dihydropteroate synthase
essential
yes
ec
2.5.1.15
synonyms
sul
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0294 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
85,737 → 86,594
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate --> diphosphate + dihydropteroate (according to UniProt)
Protein family
DHPS family (single member, according to UniProt)
[wiki|Domains]
Pterin-binding domain (aa 25-271) (according to UniProt)
Structure
[PDB|1AJZ] (from ''Escherichia coli'', 43% identity, 61% similarity) [Pubmed|9187658]
[AF|P28822]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|dusB1]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
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Time of last update: 2024-10-04 09:13:39
Author of last update: Melvin.boenninger