hisZ
168
[metabolite|ATP] phosphoribosyltransferase regulatory subunit
locus
BSU_34930
Molecular weight
43.34 kDa
pI
5.15
function
biosynthesis of [metabolite|histidine]
product
regulatory subunit for [metabolite|ATP] phosphoribosyltransferase ([protein|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG])
essential
no
synonyms
hisZ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3705 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,588,185 → 3,589,360
Phenotypes of a mutant
auxotrophic for [metabolite|histidine] [Pubmed|28189581]
The protein
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|3OD1] (from B. halodurans, 57% identity)
[AF|O34459]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
description
[Pubmed|12107147]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM] [pubmed|30355672]
regulatory mechanism
[protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM]: unknown, [pubmed|30355672], in [regulon|protein:F4097349A563503468A2A14F062AEAC532C7917A|rnpM regulon]
Biological materials
Mutant
BKE34930 (Δ[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAACCCGAGCACCTCCG, downstream forward: _UP4_CAAAATGGGTAAGTTACTCA
BKK34930 (Δ[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAACCCGAGCACCTCCG, downstream forward: _UP4_CAAAATGGGTAAGTTACTCA
References
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Time of last update: 2024-12-30 12:37:01
Author of last update: Jstuelk