folK
168
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
locus
BSU_00790
Molecular weight
18.91 kDa
pI
4.53
function
biosynthesis of folate
product
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
essential
yes
ec
2.7.6.3
synonyms
folK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0801 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
86,946 → 87,449
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
6-hydroxymethyl-7,8-dihydropterin + ATP --> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ (according to UniProt)
Protein family
HPPK family (single member, according to UniProt)
Structure
[PDB|1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) [Pubmed|12578370]
[AF|P29252]
Expression and Regulation
Operons
genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|dusB1]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Reviews
Original Publications
Page visits: 2014
Time of last update: 2024-12-20 14:25:52
Author of last update: Melvin.boenninger