ctaA
168
heme A synthase
locus
BSU_14870
Molecular weight
33.93 kDa
pI
9.64
function
heme biosynthesis
product
heme A synthase
essential
no
ec
1.3.-.-
synonyms
ctaA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1612 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,558,034 → 1,558,954
Phenotypes of a mutant
the mutant tends to acquire suppressor mutations that result in improved growth [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
heme A synthesis from protoheme IX (heme B)
Protein family
COX15/ctaA family (single member, according to UniProt)
[wiki|Domains]
contains 8 transmembrane segments
[wiki|Cofactors]
heme B
Structure
[PDB|6A2J] [pubmed|30397130]
[AF|P12946]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|B308BDECB15D68DF0EC2E49341DB5E7F9B3E14D1|ctaA]
description
[Pubmed|2549007]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972837,11325953]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|10972837,11325953], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|11325953], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|2549007,11325953], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
Biological materials
Mutant
BKE14870 (Δ[gene|B308BDECB15D68DF0EC2E49341DB5E7F9B3E14D1|ctaA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACAATATTCACCTTCTT, downstream forward: _UP4_TAAGGACTCAAGACCAAAGC
BKK14870 (Δ[gene|B308BDECB15D68DF0EC2E49341DB5E7F9B3E14D1|ctaA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACAATATTCACCTTCTT, downstream forward: _UP4_TAAGGACTCAAGACCAAAGC
References
Reviews
Original Publications
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Time of last update: 2024-10-12 13:24:30
Author of last update: Christoph.elfmann