spoIVFA
168
inhibitor of [protein|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB] metalloprotease
locus
BSU_27980
Molecular weight
29.46 kDa
pI
7.29
function
control of [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK] activation
product
inhibitor of [protein|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB] metalloprotease
essential
no
synonyms
spoIVFA, bofB, spoVL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5833 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,856,832 2,857,626
The protein
[wiki|Domains]
the ectodomain of [protein|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA] is cleaved off by [protein|DBB3ED60A7D162B9F2830F81041BC661AA5EC1E7|spoIVB] (first cleavage) [Pubmed|24243021]
the domains that inhibits [protein|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB] is cleaved off by [protein|85247AD09B7A472607B32D57E6318BA6C83EC6BA|ctpB] (second cleavage) [Pubmed|24243021]
Structure
[AF|P26936]
[wiki|Localization]
integral mother cell membrane protein [Pubmed|24243021,11959848]
Expression and Regulation
Operons
genes
[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]-[gene|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB]
description
[Pubmed|1942049]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|15699190,1942049,15383836]
regulatory mechanism
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: repression, [Pubmed|15383836], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,1942049], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
additional information
the domains that inhibits [protein|search|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [PubMed|24243021]
genes
[gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]-[gene|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB]-[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
description
[Pubmed|22383849]
regulation
expressed early during sporulation in the mother cell ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|15699190,1942049,15383836]
additional information
the domains that inhibits [protein|search|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [PubMed|24243021]
Biological materials
Mutant
BKE27980 ([gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCCATCATCCTTTGCA, downstream forward: _UP4_ATTGATCCGATTCAGGTGAT
BKK27980 ([gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27980 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCCATCATCCTTTGCA, downstream forward: _UP4_ATTGATCCGATTCAGGTGAT
References
Reviews
Original Publications
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Time of last update: 2024-12-19 19:21:47
Author of last update: Jstuelk