fadR
168
transcriptional repressor (TetR family), regulation of fatty acid degradation
locus
BSU_28550
Molecular weight
21.83 kDa
pI
6.12
function
regulation of fatty acid degradation
product
transcriptional repressor
essential
no
synonyms
fadR, ysiA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,917,957 2,918,541
The protein
Protein family
[wiki|TetR family]
[wiki|Domains]
[wiki|HTH tetR-type domain] (aa 5-65) (according to UniProt)
Structure
[PDB|3WHB] [pubmed|24356978]
[AF|P94548]
Effectors of protein activity
long chain fatty acids act as inducers that release FadR from its operator sites [Pubmed|24356978]
Expression and Regulation
Operons
genes
[gene|7AC5217CA35F8E134ABB35D74F1BA5E684D2E058|lcfA]-[gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]-[gene|3111ECB66CD3CFF0494AA3DF4D646102CF3B0FA8|fadB]-[gene|251600E5FD52DC0352A123F1224C037577F5A09C|etfB]-[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]
description
[Pubmed|17189250]
regulation
induced by long chain acyl-CoA (C14 ... C20) ([protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]) [Pubmed|17189250]
regulatory mechanism
[protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]: repression, [Pubmed|17189250], in [regulon|protein:8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|21398533], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21398533], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]-[gene|3111ECB66CD3CFF0494AA3DF4D646102CF3B0FA8|fadB]-[gene|251600E5FD52DC0352A123F1224C037577F5A09C|etfB]-[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]
description
[Pubmed|17189250]
regulation
induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]
Biological materials
Mutant
MGNA-B008 (ysiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1007 NBRP B. subtilis, Japan]
1A853 ( ''fadR''::''cat''), [Pubmed|17085570], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A853&Search=1A853 BGSC]
BKE28550 ([gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATGTTCATCGTTCCTTCC, downstream forward: _UP4_AATAAGTAAAGGAGTTCTGT
BKK28550 ([gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATGTTCATCGTTCCTTCC, downstream forward: _UP4_AATAAGTAAAGGAGTTCTGT
References
Reviews
Original Publications
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Time of last update: 2025-01-13 15:29:15
Author of last update: Jstuelk