pabC
168
aminodeoxychorismate lyase
locus
BSU_00760
Molecular weight
33.36 kDa
pI
6.12
function
biosynthesis of folate
product
aminodeoxychorismate lyase
essential
no
ec
4.1.3.38
synonyms
pabC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0115 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
84,874 85,755
The protein
Catalyzed reaction/ biological activity
4-amino-4-deoxychorismate --> 4-aminobenzoate + pyruvate (according to UniProt)
Protein family
[wiki|Class-IV pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
PLP
Structure
[PDB|5MR0] (from ''Archaeoglobus fulgidus'', 33.7% identity) [pubmed|30733943]
[AF|P28821]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|dusB1]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the [gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC] part of the mRNA is substantially stabilized upon depletion of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
Biological materials
Mutant
BKE00760 ([gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATACCGGCCGTTCACATATA, downstream forward: _UP4_ATTCATGAAAAGGGAGGAAG
BKK00760 ([gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATACCGGCCGTTCACATATA, downstream forward: _UP4_ATTCATGAAAAGGGAGGAAG
References
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Time of last update: 2025-02-12 13:03:38
Author of last update: Jstuelk