prkA

prkA
168

AAA+ ATP-dependent protease

Locus
BSU_08970
Molecular weight
72.71 kDa
Isoelectric point
5.46
Protein length
631 aaSequenceBlast
Gene length
1896 bpSequenceBlast
Function
control of SigK-dependent gene expression
Product
AAA+ ATP-dependent protease
Essential
no
Synonyms
prkA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2766 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
973,156  975,051
Phenotypes of a mutant
sporulation frequency reduced to 12-27% in knockout PubMed, due to reduced SigK expression, results from strong repression by ScoC PubMed
The protein
Catalyzed reaction/ biological activity
binds and hydrolyzes ATP PubMed
inactivation of ScoC PubMed
Protein family
prkA family (single member, according to UniProt)
Structure
P39134 (AlphaFold)
Modification
phosphorylated by PrkC on The-217 PubMed
Localization
spore coat PubMed
Additional information
the corresponding protein from E. coli (YeaG)
Expression and Regulation
Operons
Genes
prkA
Description
PubMed
Regulation
repressed by casamino acids PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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prkA

2025-04-05 23:54:55

ghost

81

edf52ee4208dc44a091b3ca3d6bb64eb40649d07

C3027F36EF2B40CA60DEEB05F0BF836494F014C7

Biological materials
Mutant
BKE08970 (prkA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGGACCTCCTCTATCA,  downstream forward: _UP4_TAAGCAACGTGACCCGTCCG
BKK08970 (prkA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGGACCTCCTCTATCA,  downstream forward: _UP4_TAAGCAACGTGACCCGTCCG
References
Reviews
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Original Publications
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83F1BE86A7AE1098C1319198A8DDA6B8C5F49236

Page visits: 5147

Time of last update: 2025-04-12 01:28:33

Author of last update: Dennis.wicke