ywbH
168
holin-like protein
locus
BSU_38320
Molecular weight
14.12 kDa
pI
9.59
function
unknown
product
holin-like protein
essential
no
synonyms
ywbH, ipa-23r, cidA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1380 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,933,209 3,933,595
Phenotypes of a mutant
a ''[gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG]'' mutant is delayed in pellicle formation [Pubmed|26060272]
a ''[gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG] [gene|E5E431AC5A7D03EEFF6D694CB25EED1570D739A2|yxaK]-[gene|5A43EDB738641C675D4136269F3638F9B609F238|yxaC] [gene|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA]-[gene|F6C3B267106E7510FABECF0B13ABF222901689A9|pftB]'' triple mutant is severely delayed in pellicle formation [Pubmed|26060272]
a ''[gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG]'' overexpression strain has more robust pellicle formation [Pubmed|26060272]
The protein
Protein family
CidA/LrgA family (with [protein|6F21B5E9EEF67E96808A1DEFA3A80DA2A0FF9462|pftA], according to UniProt)
Structure
[AF|P39591]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG]
description
[Pubmed|22383849]
regulation
induced by acetate ([protein|search|YwbI]) [Pubmed|26060272]
regulatory mechanism
[protein|CC55120C2AF455FA2AEAE39E21F57897B2B5BC39|ywbI]: activation, [Pubmed|26060272], in [regulon|protein:CC55120C2AF455FA2AEAE39E21F57897B2B5BC39|ywbI regulon]
Biological materials
Mutant
MGNA-B225 (ywbH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1224 NBRP B. subtilis, Japan]
BKE38320 ([gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE38320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGATGCCTCCCTTAT, downstream forward: _UP4_AAGAGAAAGGAGAAAAAGCA
BKK38320 ([gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK38320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTGATGCCTCCCTTAT, downstream forward: _UP4_AAGAGAAAGGAGAAAAAGCA
References
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Time of last update: 2024-12-30 11:35:09
Author of last update: Melvin.boenninger