cotA

cotA
168

laccase, bilirubin oxidase, spore coat protein (outer)

locus
BSU_06300
Molecular weight
58.33 kDa
pI
5.89
Protein length
Gene length
function
resistance of the spore
product
laccase, bilirubin oxidase
essential
no
ec
1.3.3.5
synonyms
cotA, pig

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
683,462  685,003
The protein
Protein family
S.antibioticus phenoxazinone synthase (PhsA)
[wiki|Cofactors]
Cu(I)
Structure
[PDB|2BHF] (reduced form)
[AF|P07788]
[wiki|Localization]
outer spore coat, more abundant at the mother cell-distal pole of the forespore, localization depends on [protein|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|cotE]  [Pubmed|22171814,19933362]
Expression and Regulation
Operons
genes
[gene|73473E6556D374C8623A426E075038AD01AB7025|cotA]
description
[Pubmed|22383849]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK], [protein|search|GerE]) [Pubmed|15383836]
regulatory mechanism
[protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE]: repression, [Pubmed|15383836], in [regulon|protein:19228BAD44E6DA3DE908DC390FDF628C18D94E65|gerE regulon]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|15699190,3135411], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
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[gene|73473E6556D374C8623A426E075038AD01AB7025|cotA]

2024-12-01 21:37:37

ghost

82

5a1c8f0cca9c008f3e00f24d02b46b0cc3d735e1

25610E076162668A580B3F2179E33B1E253FD43A

Biological materials
Mutant
1S101 ( ''cotA''::''cat''), [Pubmed|2821284], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S101&Search=1S101 BGSC]
1S134 ( ''cotA''::''kan''), [Pubmed|11514528], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S134&Search=1S134 BGSC]
BKE06300 ([gene|73473E6556D374C8623A426E075038AD01AB7025|cotA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCATCTGTCCTTATC,  downstream forward: _UP4_TAACCCGACAAACTTGCCTC
BKK06300 ([gene|73473E6556D374C8623A426E075038AD01AB7025|cotA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTTCATCTGTCCTTATC,  downstream forward: _UP4_TAACCCGACAAACTTGCCTC
References
Reviews
23202530
Original Publications
15699190,3135411,11514528,1518043,2821284,19933362,20200715,20551082,20822511,21369750,22281748,23859715,22171814,22410485,15383836,26062535,24293734,24733162,25259857,25847445,26784443,27050268,28870294,29301022,36133923,39235610

73473E6556D374C8623A426E075038AD01AB7025

Page visits: 5942

Time of last update: 2024-12-20 16:16:39

Author of last update: Jstuelk