lysS

lysS
168

lysyl-tRNA synthetase

locus
BSU_00820
Molecular weight
57.37 kDa
pI
5.03
Protein length
499 aaSequenceBlast
Gene length
1500 bpSequenceBlast
function
translation
product
lysyl-tRNA synthetase
essential
yes
ec
6.1.1.6
synonyms
lysS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1190 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
88,727  90,226
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-lysine + tRNALys --> AMP + diphosphate + L-lysyl-tRNALys (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|2E9I] (from ''Geobacillus stearothermophilus'', in complex with L-Lysine hydroxamate-AMP) [Pubmed|19174549]
[AF|P37477]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]

2024-12-21 16:49:21

ghost

67

5ff84b8102b086c431de43008c5bdf2220a940e9

554A7D4A7A5D1CF9E92CF08D5E78AE616950ACBA

genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|dusB1]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]→[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]

2024-12-01 21:33:19

Jstuelk

112

8c465dd3eec1aaa32d5e91206834f9bb99ef474a

7B9041CE94396BF42D285F7C0EDD3A2544761EEE

References
9084182,19174549

24CC89DE55B3C19F80B11D106B9FD241174AE3E4

Page visits: 3141

Time of last update: 2024-12-22 00:26:42

Author of last update: Melvin.boenninger