RNA switch

RNA switches are regulatory systems that rely on alternative mRNA structures.

RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)

List of Bacillus subtilis RNAswitches

• Protein-dependent RNA switches
  • L20 leader: in front of the infC-rpmI-rplT-ysdA operon: controlled by RplT binding
  • ptsG-ptsH-ptsI: controlled by GlcT
  • sacX-sacY, sacB: controlled by SacY
  • sacP-sacA: controlled by SacT
  • bglS, bglP-bglH: controlled by BglP

• T-box

• Riboswitches
  • A-box
  • FMN-box
  • G-box
  • Gly-box
  • L-box
  • M-box
  • preQ1 riboswitch
  • ribozyme: glmS
  • S-box
  • Thi-box

• Potential additional RNA switches

The function of these potential RNA structures is unknown. They were suggested to control the mentioned genes.

• • ydaO-yuaA switch: ydaO, ktrA
  • ykkC-yxkD switch: ykkC, yxkD
  • yybP-ykoY switch: yybP, ykoY
  • ylbH switch: ylbH
  • L10 leader: rplJ
  • L13 leader: rplM
  • L19 leader: rplS
  • L21_leader:in front of the rplU-ysxB-rpmA operon

Important Reviews

<pubmed>15063848 , 19250859 ,19141470 , 17092822, 17764952 ,17381303, 16226486 , 16153177 , 15750802, 14523920 18430893 </pubmed>