Revision as of 13:42, 2 April 2014

Description: malonyl CoA-acyl carrier protein transacylase

Gene name	fabD
Synonyms	ylpE
Essential	yes PubMed
Product	malonyl CoA-acyl carrier protein transacylase
Function	fatty acid biosynthesis
*Gene expression levels in SubtiExpress*: fabD
Metabolic function and regulation of this protein in SubtiPathways: fabD
MW, pI	33 kDa, 4.515
Gene length, protein length	951 bp, 317 aa
Immediate neighbours	plsX, fabG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

biosynthesis of lipids, essential genes

This gene is a member of the following regulons

ComA regulon, FapR regulon

The gene

Basic information

Locus tag: BSU15900

Phenotypes of a mutant

essential PubMed

Database entries

BsubCyc: BSU15900

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein] (according to Swiss-Prot)

Protein family: fabD family (according to Swiss-Prot)

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:

Localization:

Database entries

BsubCyc: BSU15900

Structure: 1MLA (the enzyme from E. coli) PubMed

UniProt: P71019

KEGG entry: [3]

E.C. number: 2.3.1.39

Additional information

Expression and regulation

Operon: fapR-plsX-fabD-fabG-acpA PubMed

Expression browser: fabD PubMed

Sigma factor: SigA PubMed

Regulation:
- induced if the cells experience an accumulation of malonyl-CoA (FapR) PubMed
- expressed at high cell density (ComA) PubMed

Regulatory mechanism:
- ComA: transcription activation (ComA) PubMed
- FapR: transcription repression PubMed

Additional information:

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications

@@ Line 62: / Line 62: @@
 === Database entries ===
+* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15900&redirect=T BSU15900]
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fapR-plsX-fabDG.html]
@@ Line 99: / Line 100: @@
 === Database entries ===
+* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15900&redirect=T BSU15900]
 * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1MLA 1MLA] (the enzyme from ''E. coli'') {{PubMed|7768883}}