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m Jstuelk moved page YwbN to EfeB: 23764491
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* '''Description:''' elemental iron uptake system (binding protein) <br/><br/>
* '''Description:''' elemental iron uptake system, heme peroxidase converts ferrous iron (Fe(II) to ferric iron (FeIII)) for uptake by EfeO-EfeU, peroxide detoxification under microaerobic conditions<br/><br/>


{| align="right" border="1" cellpadding="2"  
{| align="right" border="1" cellpadding="2"  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ywbN''
|''efeB''
|-
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-29d ''
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-29d, ywbN ''
|-
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
|-
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || elemental iron uptake system (binding protein)
|style="background:#ABCDEF;" align="center"| '''Product''' || elemental iron uptake  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || iron uptake
|style="background:#ABCDEF;" align="center"|'''Function''' || ferrous iron conversion
|-
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38260 ywbN]
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38260 efeB]
|-
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YwbN YwbN]
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/EfeB EfeB]
|-
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1248 bp, 416 aa  
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1248 bp, 416 aa  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywbO]]'', ''[[ywbM]]''
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywbO]]'', ''[[efeO]]''
|-
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38260 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38260 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38260 DNA_with_flanks]
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38260 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38260 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38260 DNA_with_flanks]
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* '''[[SubtInteract|Interactions]]:'''
* '''[[SubtInteract|Interactions]]:'''
** ([[YwbL]]-[[YwbM]])-[[YwbN]] {{PubMed|23180473}}
** [[EfeO]]-[[EfeU]]-[[EfeB]] {{PubMed|23180473,23764491}}


* '''[[Localization]]:'''  
* '''[[Localization]]:'''  
** extracellular, secreted by the [[TatAY]]-[[TatCY]] complex {{PubMed|15554971}}
** extracellular, secreted by the [[TatAY]]-[[TatCY]] complex {{PubMed|15554971}}
** [[TatAY]]-[[TatCY]]-dependent export of [[YwbN]] requires a functional [[WprA]] {{PubMed|23180473}}
** [[TatAY]]-[[TatCY]]-dependent export of [[EfeB]] requires a functional [[WprA]] {{PubMed|23180473}}
** forms a membrane-bound complex with [[YwbM]] and [[YwbL]] for iron uptake {{PubMed|23180473}}
** forms a membrane-bound complex with [[EfeU]] and [[EfeO]] for iron uptake {{PubMed|23180473,23764491}}
** attached to the membrane via [[EfeU]] {{PubMed|23764491}}


=== Database entries ===
=== Database entries ===
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=Expression and regulation=
=Expression and regulation=
* '''Operon:'''  
* '''Operon:'''  
** ''[[ywbL]]-[[ywbM]]-[[ywbN]]'' {{PubMed|9353933}}
** ''[[efeU]]-[[efeO]]-[[efeB]]'' {{PubMed|9353933}}
** ''[[ywbN]]-[[ywbO]]'' {{PubMed|18179421}}
** ''[[efeB]]-[[ywbO]]'' {{PubMed|18179421}}


* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=efeN_3926682_3927932_-1 ywbN] {{PubMed|22383849}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=efeN_3926682_3927932_-1 efeB] {{PubMed|22383849}}


* '''[[Sigma factor]]:'''  
* '''[[Sigma factor]]:'''  
** ''[[ywbN]]'': [[SigM]] {{PubMed|18179421}}, [[SigX]], [[SigW]] {{PubMed|9683469}}
** ''[[efeU]]'': [[SigA]] {{PubMed|23764491}}
** ''[[efeB]]'': [[SigM]] {{PubMed|18179421}}, [[SigX]], [[SigW]] {{PubMed|9683469}}


* '''Regulation:'''  
* '''Regulation:'''  
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=References=
=References=
<pubmed>16672620,19180538,12354229, 19383693 9353933 9683469 15554971 21479178 18179421 22923395 23180473 23560556 </pubmed>
<pubmed>16672620,19180538,12354229, 19383693 9353933 9683469 15554971 21479178 18179421 22923395 23180473 23560556 23764491 </pubmed>


[[Category:Protein-coding genes]]
[[Category:Protein-coding genes]]

Revision as of 16:12, 21 June 2013

  • Description: elemental iron uptake system, heme peroxidase converts ferrous iron (Fe(II) to ferric iron (FeIII)) for uptake by EfeO-EfeU, peroxide detoxification under microaerobic conditions

Gene name efeB
Synonyms ipa-29d, ywbN
Essential no
Product elemental iron uptake
Function ferrous iron conversion
Gene expression levels in SubtiExpress: efeB
Interactions involving this protein in SubtInteract: EfeB
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 45 kDa, 8.64
Gene length, protein length 1248 bp, 416 aa
Immediate neighbours ywbO, efeO
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

transporters/ other, acquisition of iron, iron metabolism, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

Fur regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

  • Locus tag: BSU38260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: DyP-type peroxidase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Your additional remarks

References

<pubmed>16672620,19180538,12354229, 19383693 9353933 9683469 15554971 21479178 18179421 22923395 23180473 23560556 23764491 </pubmed>

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