RNA switch: Difference between revisions

Revision as of 19:18, 3 February 2010

RNA switches are regulatory systems that rely on alternative mRNA structures.

RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)

Protein-dependent RNA switches
- L20 leader: in front of the infC-rpmI-rplT-ysdA operon: controlled by RplT binding
- ptsG-ptsH-ptsI: controlled by GlcT
- sacX-sacY, sacB: controlled by SacY
- sacP-sacA: controlled by SacT
- bglS, bglP-bglH-yxiE: controlled by BglP
- glpD, glpF-glpK, glpT-glpQ: controlled by GlpP
- pabA, trpE-trpD-trpC-trpF-trpB-trpA, trpP, ycbK: controlled by TRAP
- hutH-hutU-hutI-hutG-hutM: controlled by HutP
- pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE: controlled by PyrR

Riboswitches
- A-box
- FMN-box
- G-box
- Gly-box
- L-box
- M-box
- preQ1 riboswitch
- ribozyme: glmS
- S-box
- Thi-box

Potential additional RNA switches
- pyrG RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the pyrG mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the pyrG leader. PubMed

The function of the following potential RNA structures is unknown. They were suggested to control the mentioned genes.

@@ Line 31: / Line 31: @@
 * '''Potential additional RNA switches'''
-The function of these potential RNA structures is unknown. They were suggested to control the mentioned genes.
+** ''[[pyrG]]'' RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the ''[[pyrG]]'' mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the ''[[pyrG]]'' leader. {{PubMed|17302819}}
+The function of the following potential RNA structures is unknown. They were suggested to control the mentioned genes.
 ** [http://rfam.sanger.ac.uk/family?acc=RF00379 ydaO-yuaA switch]: ''[[ydaO]], [[ktrA]]''