YhxA

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  • Description: similar to adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene name yhxA
Synonyms
Essential no
Product unknown
Function unknown
Gene expression levels in SubtiExpress: yhxA
MW, pI 49 kDa, 5.644
Gene length, protein length 1350 bp, 450 aa
Immediate neighbours yhcX, glpP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YhxA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YhxA expression.png


























Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • half-life of the mRNA: 3.7 min PubMed
    • the mRNA is stabilized in rppH and rnjA mutants PubMed
    • the mRNA is subject to degradation by RNase J1 PubMed
    • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jamie Richards, Quansheng Liu, Olivier Pellegrini, Helena Celesnik, Shiyi Yao, David H Bechhofer, Ciarán Condon, Joel G Belasco
An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis.
Mol Cell: 2011, 43(6);940-9
[PubMed:21925382] [WorldCat.org] [DOI] (I p)

Ulf Gerth, Holger Kock, Ilja Kusters, Stephan Michalik, Robert L Switzer, Michael Hecker
Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis.
J Bacteriol: 2008, 190(1);321-31
[PubMed:17981983] [WorldCat.org] [DOI] (I p)

C Holmberg, L Beijer, B Rutberg, L Rutberg
Glycerol catabolism in Bacillus subtilis: nucleotide sequence of the genes encoding glycerol kinase (glpK) and glycerol-3-phosphate dehydrogenase (glpD).
J Gen Microbiol: 1990, 136(12);2367-75
[PubMed:2127799] [WorldCat.org] [DOI] (P p)