RsgI

• Description: regulator of SigI activity
  
  

Gene name	rsgI
Synonyms	ykrI
Essential	no
Product	anti-sigma factor
Function	control of SigI activity
Gene expression levels in SubtiExpress: rsgI
Interactions involving this protein in SubtInteract: RsgI
Metabolic function and regulation of this protein in SubtiPathways: rsgI
MW, pI	43 kDa, 4.517
Gene length, protein length	1143 bp, 381 aa
Immediate neighbours	sigI, sspD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, heat shock proteins, membrane proteins

This gene is a member of the following regulons

SigI regulon

The gene

Basic information

• Locus tag: BSU13460

Phenotypes of a mutant

suppresses the growth defect of a mbl mutation PubMed

Database entries

• BsubCyc: BSU13460

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: anti-sigma factor for SigI PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsgI-SigI PubMed

• Localization:
  • membrane PubMed

Database entries

• BsubCyc: BSU13460

• Structure:

• UniProt: O31655

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sigI-rsgI PubMed

• Expression browser: rsgI PubMed

• Sigma factor: SigI PubMed

• Regulation:
  • induced at high temperature (SigI, WalR) PubMed

• Regulatory mechanism:
  • WalR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Letal I Salzberg, Leagh Powell, Karsten Hokamp, Eric Botella, David Noone, Kevin M Devine
The WalRK (YycFG) and σ(I) RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells.
Mol Microbiol: 2013, 87(1);180-95
[PubMed:23199363] [WorldCat.org] [DOI] (I p)

Kathrin Schirner, Jeff Errington
The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis.
J Bacteriol: 2009, 191(5);1404-13
[PubMed:19114499] [WorldCat.org] [DOI] (I p)

Kei Asai, Takafumi Ootsuji, Kazue Obata, Takashi Matsumoto, Yasutaro Fujita, Yoshito Sadaie
Regulatory role of RsgI in sigI expression in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 1);92-101
[PubMed:17185538] [WorldCat.org] [DOI] (P p)