Replisome

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The replisome is a protein complex that is required and sufficient for replication of both leading and lagging strands.

PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed

RecA colocalizes to the replisome in response to endogenous and exogenous DNA damage and in response to damage-independent fork arrest (formation of DNA repair centers), repair center formation depends on RecO and RecR, and is facilitated by RecF and SsbA PubMed

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Back to Protein-protein interactions

In vitro reconstitution of the replisome


Reviews


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