AppC

• Description: oligopeptide ABC transporter (permease)
  
  

Gene name	appC
Synonyms
Essential	no
Product	oligopeptide ABC transporter (permease))
Function	uptake of oligopeptides
Gene expression levels in SubtiExpress: appC
Interactions involving this protein in SubtInteract: AppC
Metabolic function and regulation of this protein in SubtiPathways: appC
MW, pI	33 kDa, 9.777
Gene length, protein length	909 bp, 303 aa
Immediate neighbours	appB, yjbA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, utilization of nitrogen sources other than amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, ScoC regulon

The gene

Basic information

• Locus tag: BSU11400

Database entries

• BsubCyc: BSU11400

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transmembrane type-1 domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (AppD-AppF)-(AppB-AppC)-AppA PubMed

• Localization: cell membrane PubMed

Database entries

• BsubCyc: BSU11400

• Structure:

• UniProt: P42063

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: appD-appF-appA-appB-appC PubMed

• Expression browser: appC PubMed

• Sigma factor:

• Regulation:
  • repressed during exponential growth (ScoC) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • ScoC: transcription repression PubMed
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP2100 (D(appD-appF-appA-appB-appC)::spc), available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: