KipA

• Description: antagonist of KipI, control of the phosphorelay
  
  

Gene name	kipA
Synonyms
Essential	no
Product	antagonist of KipI
Function	control of the phosphorelay, initiation of sporulation
Gene expression levels in SubtiExpress: kipA
Interactions involving this protein in SubtInteract: KipA
Function and regulation of this protein in SubtiPathways: kipA
MW, pI	36 kDa, 5.465
Gene length, protein length	1011 bp, 337 aa
Immediate neighbours	kipI, kipR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphorelay

This gene is a member of the following regulons

KipR regulon, TnrA regulon

The gene

Basic information

• Locus tag: BSU04090

Database entries

• BsubCyc: BSU04090

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: KipA-KipI PubMed

• Localization:

Database entries

• BsubCyc: BSU04090

• Structure:

• UniProt: Q7WY77

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ycsF-ycsG-ycsI-kipI-kipA-kipR-lipC PubMed

• Expression browser: kipA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • KipR: transcription repression PubMed
  • TnrA: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 290 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

David A Jacques, David B Langley, Robert M G Hynson, Andrew E Whitten, Ann Kwan, J Mitchell Guss, Jill Trewhella
A novel structure of an antikinase and its inhibitor.
J Mol Biol: 2011, 405(1);214-26
[PubMed:21050859] [WorldCat.org] [DOI] (I p)

L Wang, R Grau, M Perego, J A Hoch
A novel histidine kinase inhibitor regulating development in Bacillus subtilis.
Genes Dev: 1997, 11(19);2569-79
[PubMed:9334321] [WorldCat.org] [DOI] (P p)