MenB

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  • Description: naphthoate synthase

Gene name menB
Synonyms
Essential yes PubMed
Product naphthoate synthase
Function biosynthesis of menaquinone
Gene expression levels in SubtiExpress: menB
Metabolic function and regulation of this protein in SubtiPathways:
menB
MW, pI 29 kDa, 5.343
Gene length, protein length 813 bp, 271 aa
Immediate neighbours menE, ytxM
Sequences Protein DNA DNA_with_flanks
Genetic context
MenB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MenB expression.png




























Categories containing this gene/protein

biosynthesis of cofactors, essential genes, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU30800

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: o-succinylbenzoyl-CoA = CoA + 1,4-dihydroxy-2-naphthoate (according to Swiss-Prot)
  • Protein family: enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-78 and Arg-269 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1RJM (from Mycobacterium tuberculosis, 48% identity, 61% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 929 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 2531 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References