MoaE

• Description: molybdopterin synthase (large subunit), catalyses the transfer of sulfide from MoaD thiocarboxylate
  
  

Gene name	moaE
Synonyms
Essential	no
Product	molybdopterin synthase (large subunit)
Function	nitrate respiration
Gene expression levels in SubtiExpress: moaE
Interactions involving this protein in SubtInteract: MoaE
Metabolic function and regulation of this protein in SubtiPathways: MoaE
MW, pI	17 kDa, 4.746
Gene length, protein length	471 bp, 157 aa
Immediate neighbours	mobB, moaD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU14300

Database entries

• BsubCyc: BSU14300

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: catalyses the transfer of sulfide from MoaD thiocarboxylate

• Protein family: moaE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • MoaD-MoaE (as deduced from E. coli, PubMed)

• Localization:

Database entries

• BsubCyc: BSU14300

• Structure:
  • 1NVI (the MoaD-MoaE complex from E. coli) PubMed

• UniProt: O31705

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mobA-moeB-moeA-mobB-moaE-moaD PubMed

• Expression browser: moaE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Ralf R Mendel
The molybdenum cofactor.
J Biol Chem: 2013, 288(19);13165-72
[PubMed:23539623] [WorldCat.org] [DOI] (I p)

Tadhg P Begley, Steven E Ealick, Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochem Soc Trans: 2012, 40(3);555-60
[PubMed:22616866] [WorldCat.org] [DOI] (I p)