LipL

• Description: GcvH : E2 amidotransferase
  
  

Gene name	lipL
Synonyms	ipa-90d, ywfL
Essential	no
Product	GcvH : E2 amidotransferase
Function	lipoic acid metabolism
Gene expression levels in SubtiExpress: lipL
Metabolic function and regulation of this protein in SubtiPathways: LipL
MW, pI	31 kDa, 5.266
Gene length, protein length	843 bp, 281 aa
Immediate neighbours	ywfM, cysL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

Biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU37640

Database entries

• BsubCyc: BSU37640

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU37640

• Structure:

• UniProt: P39648

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywfL PubMed

• Expression browser: lipL PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Quin H Christensen, Natalia Martin, Maria C Mansilla, Diego de Mendoza, John E Cronan
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
Mol Microbiol: 2011, 80(2);350-63
[PubMed:21338421] [WorldCat.org] [DOI] (I p)

Natalia Martin, Quin H Christensen, María C Mansilla, John E Cronan, Diego de Mendoza
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
Mol Microbiol: 2011, 80(2);335-49
[PubMed:21338420] [WorldCat.org] [DOI] (I p)

E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933] [WorldCat.org] [DOI] (P p)