VmlR

• Description: ABC transporter (ATP-binding protein), efflux of antibiotics (virginiamycin M, lincomycin)
  
  

Gene name	vmlR
Synonyms	expZ
Essential	no
Product	antibiotic efflux ABC transporter (ATP-binding protein)
Function	efflux of antibiotics (virginiamycin M, lincomycin)
Gene expression levels in SubtiExpress: vmlR
MW, pI	62 kDa, 6.727
Gene length, protein length	1641 bp, 547 aa
Immediate neighbours	ydgE, ydgF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics

This gene is a member of the following regulons

RNA switch/ other

The gene

Basic information

• Locus tag: BSU05610

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39115

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: vmlR PubMed

• Expression browser: vmlR PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by virginiamycin M or lincomycin PubMed

• Regulatory mechanism: transcriptional antitermination, details are unknown PubMed

• Additional information:
  • A ncRNA is predicted between vmlR and ydgF PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Chloé Hot, Nicolas Berthet, Olivier Chesneau
Characterization of sal(A), a novel gene responsible for lincosamide and streptogramin A resistance in Staphylococcus sciuri.
Antimicrob Agents Chemother: 2014, 58(6);3335-41
[PubMed:24687494] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Reiko Ohki, Kozue Tateno, Teruaki Takizawa, Toshiko Aiso, Makiko Murata
Transcriptional termination control of a novel ABC transporter gene involved in antibiotic resistance in Bacillus subtilis.
J Bacteriol: 2005, 187(17);5946-54
[PubMed:16109936] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)