Epr

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  • Description: minor extracellular serine protease, involved in control of swarming motility PubMed

Gene name epr
Synonyms ipa-15r
Essential no
Product minor extracellular serine protease
Function protein degradation
Gene expression levels in SubtiExpress: epr
MW, pI 69 kDa, 9.875
Gene length, protein length 1935 bp, 645 aa
Immediate neighbours ywbA, sacX
Sequences Protein DNA DNA_with_flanks
Genetic context
Epr context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Epr expression.png















Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, proteolysis, motility and chemotaxis

This gene is a member of the following regulons

DegU regulon, ScoC regulon, SigD regulon, SinR regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU38400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: peptidase S8 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Original publications

Susanne Pohl, Gaurav Bhavsar, Joanne Hulme, Alexandra E Bloor, Goksel Misirli, Matthew W Leckenby, David S Radford, Wendy Smith, Anil Wipat, E Diane Williamson, Colin R Harwood, Rocky M Cranenburgh
Proteomic analysis of Bacillus subtilis strains engineered for improved production of heterologous proteins.
Proteomics: 2013, 13(22);3298-308
[PubMed:24115457] [WorldCat.org] [DOI] (I p)

Monica Gupta, Madhulika Dixit, K Krishnamurthy Rao
Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis.
J Biosci: 2013, 38(2);291-9
[PubMed:23660663] [WorldCat.org] [DOI] (I p)

Monica Gupta, Kestur Krishnamurthy Rao
Epr plays a key role in DegU-mediated swarming motility of Bacillus subtilis.
FEMS Microbiol Lett: 2009, 295(2);187-94
[PubMed:19416356] [WorldCat.org] [DOI] (I p)

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)

Prashant Kodgire, Madhulika Dixit, K Krishnamurthy Rao
ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis.
J Bacteriol: 2006, 188(17);6425-8
[PubMed:16923912] [WorldCat.org] [DOI] (P p)

Madhulika Dixit, Charuta S Murudkar, K Krishnamurthy Rao
Epr is transcribed from a final sigma(D) promoter and is involved in swarming of Bacillus subtilis.
J Bacteriol: 2002, 184(2);596-9
[PubMed:11751842] [WorldCat.org] [DOI] (P p)

A Sloma, A Ally, D Ally, J Pero
Gene encoding a minor extracellular protease in Bacillus subtilis.
J Bacteriol: 1988, 170(12);5557-63
[PubMed:3142851] [WorldCat.org] [DOI] (P p)