HelD

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  • Description: DNA 3'-5' helicase IV, stimulates transcription in an ATP-dependent manner by enhancing transcriptional cycling and elongation

Gene name helD
Synonyms yvgS
Essential no
Product DNA 3'-5' helicase IV
Function transcription, DNA repair/ recombination
Gene expression levels in SubtiExpress: helD
MW, pI 89 kDa, 6.083
Gene length, protein length 2322 bp, 774 aa
Immediate neighbours cysI, yvgT
Sequences Protein DNA DNA_with_flanks
Genetic context
YvgS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HelD expression.png















Categories containing this gene/protein

DNA repair/ recombination, transcription

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU33450

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: UvrD subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 3DMN (C-terminal domain of the protein from Lactobacillus plantarum, 39% identity)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
    • 1A899 ( helD::erm), available at BGSC
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jana Wiedermannová, Petra Sudzinová, Tomaš Kovaľ, Alžbeta Rabatinová, Hana Šanderova, Olga Ramaniuk, Šimon Rittich, Jan Dohnálek, Zhihui Fu, Petr Halada, Peter Lewis, Libor Krásny
Characterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis.
Nucleic Acids Res: 2014, 42(8);5151-63
[PubMed:24520113] [WorldCat.org] [DOI] (I p)