SpoIIAB
- Description: anti-SigF/ protein serine kinase
Gene name | spoIIAB |
Synonyms | |
Essential | no |
Product | anti-SigF/ protein serine kinase |
Function | control of SigF activity septation; phosphorylation and inactivation of SpoIIAA |
Gene expression levels in SubtiExpress: spoIIAB | |
Interactions involving this protein in SubtInteract: SpoIIAB | |
Metabolic function and regulation of this protein in SubtiPathways: spoIIAB | |
MW, pI | 16 kDa, 4.383 |
Gene length, protein length | 438 bp, 146 aa |
Immediate neighbours | sigF, spoIIAA |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
protein modification, sigma factors and their control, sporulation proteins
This gene is a member of the following regulons
AbrB regulon, SigF regulon, SigG regulon, SigH regulon, SinR regulon, Spo0A regulon
The gene
Basic information
- Locus tag: BSU23460
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + a protein = ADP + a phosphoprotein (according to Swiss-Prot)
- Protein family: anti-sigma-factor family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1L0O (complex with SigF, Geobacillus stearothermophilus), 1TIL (complex with SpoIIAA, Geobacillus stearothermophilus)
- UniProt: P10728
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Charles Moran, Emory University, NC, USA homepage
Your additional remarks
References
Modeling of SigF activation
Georgios Fengos, Dagmar Iber
Prediction stability in a data-based, mechanistic model of σF regulation during sporulation in Bacillus subtilis.
Sci Rep: 2013, 3;2755
[PubMed:24067622]
[WorldCat.org]
[DOI]
(I e)
Dagmar Iber
Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case.
Adv Bioinformatics: 2011, 2011;124062
[PubMed:22312331]
[WorldCat.org]
[DOI]
(I p)
Jin Hwan Do, Masao Nagasaki, Satoru Miyano
The systems approach to the prespore-specific activation of sigma factor SigF in Bacillus subtilis.
Biosystems: 2010, 100(3);178-84
[PubMed:20298743]
[WorldCat.org]
[DOI]
(I p)
Original Publications