PgcA

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  • Description: alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)

Gene name pgcA
Synonyms yhxB, gtaC, gtaE
Essential no
Product alpha-phosphoglucomutase
Function interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
Gene expression levels in SubtiExpress: pgcA
Metabolic function and regulation of this protein in SubtiPathways:
pgcA
MW, pI 62 kDa, 4.913
Gene length, protein length 1695 bp, 565 aa
Immediate neighbours glpD, yhcY
Sequences Protein DNA DNA_with_flanks
Genetic context
YhxB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PgcA expression.png















Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09310

Phenotypes of a mutant

  • the inactivation of pgcA suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)
  • Protein family: phosphohexose mutase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications