SpoVD

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Gene name spoVD
Synonyms
Essential no
Product penicillin-binding protein (spore cortex)
Function spore morphogenesis
Gene expression levels in SubtiExpress: spoVD
Interactions involving this protein in SubtInteract: SpoVD
MW, pI 71 kDa, 8.85
Gene length, protein length 1935 bp, 645 aa
Immediate neighbours pbpB, murE
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoVD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoVD expression.png















Categories containing this gene/protein

cell wall synthesis, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

  • Locus tag: BSU15170

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: protects SpoVE from proteolytic degradation PubMed
  • Protein family:
  • Paralogous protein(s): PbpB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: intramolecular disulfide bonds between two Cys residues are reduced by StoA, this is rquired for activity of SpoVD PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed during sporulation in the mother cell (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Patrick Eichenberger
The red-ox status of a penicillin-binding protein is an on/off switch for spore peptidoglycan synthesis in Bacillus subtilis.
Mol Microbiol: 2010, 75(1);10-2
[PubMed:19919674] [WorldCat.org] [DOI] (I p)

Original Publications