YvmC

• Description: cyclodipeptide synthase
  
  

Gene name	yvmC
Synonyms
Essential	no
Product	cyclodipeptide synthase
Function	biosynthesis of the extracellular iron chelate pulcherrimin
Gene expression levels in SubtiExpress: yvmC
MW, pI	28 kDa, 6.612
Gene length, protein length	744 bp, 248 aa
Immediate neighbours	cypX, yvmB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

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Categories containing this gene/protein

acquisition of iron, iron metabolism

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU35070

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3S7T (from B. licheniformis, 70% identity, 86% similarity) PubMed

• UniProt: O34351

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yvmC-cypX Reference

• Expression browser: yvmC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Luc Bonnefond, Taiga Arai, Yuriko Sakaguchi, Tsutomu Suzuki, Ryuichiro Ishitani, Osamu Nureki
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog.
Proc Natl Acad Sci U S A: 2011, 108(10);3912-7
[PubMed:21325056] [WorldCat.org] [DOI] (I p)

Muriel Gondry, Ludovic Sauguet, Pascal Belin, Robert Thai, Rachel Amouroux, Carine Tellier, Karine Tuphile, Mickaël Jacquet, Sandrine Braud, Marie Courçon, Cédric Masson, Steven Dubois, Sylvie Lautru, Alain Lecoq, Shin-ichi Hashimoto, Roger Genet, Jean-Luc Pernodet
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
Nat Chem Biol: 2009, 5(6);414-20
[PubMed:19430487] [WorldCat.org] [DOI] (I p)

S H Harrison
The surgical management of the arthritic hand.
Ann R Coll Surg Engl: 1979, 61(1);17-28
[PubMed:420491] [WorldCat.org] (P p)

additional paper