RibD

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  • Description: 5-amino-6-(5-phosphoribosylamino)uracil reductase

Gene name ribD
Synonyms ribG
Essential no
Product 5-amino-6-(5-phosphoribosylamino)uracil reductase
Function riboflavin biosynthesis
Gene expression levels in SubtiExpress: ribD
Metabolic function and regulation of this protein in SubtiPathways:
Riboflavin / FAD
MW, pI 39 kDa, 6.079
Gene length, protein length 1083 bp, 361 aa
Immediate neighbours ribE, ypuD
Sequences Protein DNA DNA_with_flanks
Genetic context
RibD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RibD expression.png















Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

FMN-box

The gene

Basic information

  • Locus tag: BSU23280

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3 (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism: FMN-box: riboswitch, mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed