RibD

• Description: 5-amino-6-(5-phosphoribosylamino)uracil reductase
  
  

Gene name	ribD
Synonyms	ribG
Essential	no
Product	5-amino-6-(5-phosphoribosylamino)uracil reductase
Function	riboflavin biosynthesis
Gene expression levels in SubtiExpress: ribD
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	39 kDa, 6.079
Gene length, protein length	1083 bp, 361 aa
Immediate neighbours	ribE, ypuD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

FMN-box

The gene

Basic information

• Locus tag: BSU23280

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H₂O = 5-amino-6-(5-phosphoribosylamino)uracil + NH₃ (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3EX8 PubMed

• UniProt: P17618

• KEGG entry: [3]

• E.C. number: 3.5.4.26, 1.1.1.193

Expression and regulation

• Operon: ribD-ribE-ribA-ribH-ribT PubMed

• Expression browser: ribD PubMed

• Sigma factor: SigA PubMed

• Regulation: expressed in the absence of FMN (FMN-box) PubMed

• Regulatory mechanism: FMN-box: riboswitch, mediates termination/ antitermination control of the operon, in the absence of FMN: antitermination, in the presence of FMN: termination PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed