NtdC

• Description: NAD-dependent glucose-6-phosphate dehydrogenase
  
  

Gene name	ntdC
Synonyms	yhjJ
Essential	no
Product	NAD-dependent glucose-6-phosphate dehydrogenase
Function	synthesis of the antibiotic kanosamine
Gene expression levels in SubtiExpress: ntdC
MW, pI	39 kDa, 6.227
Gene length, protein length	1050 bp, 350 aa
Immediate neighbours	glcP, ntdB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

NtdR regulon

The gene

Basic information

• Locus tag: BSU10530

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • glucose-6-phosphate + NAD --> 3-oxo-d-glucose-6-phosphate + NADH(2) PubMed

• Protein family: gfo/idh/mocA family (according to Swiss-Prot)

• Paralogous protein(s): YfiI, YrbE, YteT, YulF, IolW, IolX, IolG

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):
  • NAD(+) PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07564

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ntdA-ntdB-ntdC-glcP PubMed

• Expression browser: ntdC PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by 3,3'-neotrehalosadiamine (NtdR) PubMed

• Regulatory mechanism: NtdR: positive regulator PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Takashi Inaoka, Kozo Ochi
Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.
Biosci Biotechnol Biochem: 2011, 75(4);618-23
[PubMed:21512256] [WorldCat.org] [DOI] (I p)