Dra

• Description: deoxyribose-phosphate aldolase
  
  

Gene name	dra
Synonyms	deoC
Essential	no
Product	deoxyribose-phosphate aldolase
Function	utilization of nucleotides as carbon source
Gene expression levels in SubtiExpress: dra
Metabolic function and regulation of this protein in SubtiPathways: Nucleoside catabolism, Nucleotides (regulation)
MW, pI	22 kDa, 4.926
Gene length, protein length	633 bp, 211 aa
Immediate neighbours	nupC, deoR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

utilization of nucleotides

This gene is a member of the following regulons

CcpA regulon, DeoR regulon

The gene

Basic information

• Locus tag: BSU39420

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde (according to Swiss-Prot)

• Protein family: DeoC type 1 subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1MZH (from Aquifex aeolicus, 42% identity, 62% similarity)

• UniProt: P39121

• KEGG entry: [3]

• E.C. number: 4.1.2.4

Expression and regulation

• Operon: dra-nupC-pdp PubMed

• Expression browser: dra PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed
  • induced by deoxynucleotides (DeoR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • DeoR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: