SdpR

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  • Description: transcriptional repressor of the sdpR-sdpI operon

Gene name sdpR
Synonyms yvbA
Essential no
Product transcriptional regulator (ArsR family)
Function regulation of protection against SdpC
Gene expression levels in SubtiExpress: sdpR
Interactions involving this protein in SubtInteract: SdpR
MW, pI 10 kDa, 7.328
Gene length, protein length 270 bp, 90 aa
Immediate neighbours sdpI, opuCD
Sequences Protein DNA Advanced_DNA
Genetic context
YvbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SdpR expression.png
























Categories containing this gene/protein

transcription factors and their control, toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, SdpR regulon

The SdpR regulon:

The gene

Basic information

  • Locus tag: BSU33790

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: SdpI binds and sequesters SdpR if extracellular SdpC is present, this results in induction of the sdpR-sdpI operon PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)

Original Publications

Craig D Ellermeier, Errett C Hobbs, Jose E Gonzalez-Pastor, Richard Losick
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.
Cell: 2006, 124(3);549-59
[PubMed:16469701] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)

M S Turner, J D Helmann
Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis.
J Bacteriol: 2000, 182(18);5202-10
[PubMed:10960106] [WorldCat.org] [DOI] (P p)