GcvH

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  • Description: glycine cleavage system protein H, 2-oxo acid dehydrogenase, lipoyl-binding site

Gene name gcvH
Synonyms yusH
Essential no
Product glycine cleavage system protein H
Function glycine utilization
Gene expression levels in SubtiExpress: gcvH
MW, pI 14 kDa, 3.888
Gene length, protein length 381 bp, 127 aa
Immediate neighbours yusG, yusI
Sequences Protein DNA Advanced_DNA
Genetic context
GcvH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GcvH expression.png
























Categories containing this gene/protein

utilization of amino acids, Biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU32800

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: gcvH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): lipoic acid, lipoylated by LipM PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additonal publications: PubMed

Quin H Christensen, John E Cronan
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases.
Biochemistry: 2010, 49(46);10024-36
[PubMed:20882995] [WorldCat.org] [DOI] (I p)