CoaX

• Description: hypothetical protein
  
  

Gene name	coaX
Synonyms	yacB
Essential	no
Product	pantothenate kinase (EC 2.7.1.33)
Function	coenyzmeA synthesis
Gene expression levels in SubtiExpress: coaX
Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A
MW, pI	26 kDa, 8.37
Gene length, protein length	699 bp, 233 aa
Immediate neighbours	ftsH, yacC
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

• Locus tag: BSU00700

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

• Protein family: type III pantothenate kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2H3G (from Bacillus anthracis str. ames, 75% identity, 88% similarity) PubMed

• UniProt: P37564

• KEGG entry: [2]

• E.C. number: 2.7.1.33

Expression and regulation

• Operon: coaX-yacC PubMed

• Expression browser: coaX PubMed

• Sigma factor: SigM PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Leisl A Brand, Erick Strauss
Characterization of a new pantothenate kinase isoform from Helicobacter pylori.
J Biol Chem: 2005, 280(21);20185-8
[PubMed:15795230] [WorldCat.org] [DOI] (P p)