HlpB

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  • Description: HNH nuclease-like protein

Gene name hlpB
Synonyms yisB
Essential no
Product HNH nuclease-like protein
Function unknown
Gene expression levels in SubtiExpress: yisB
MW, pI 11 kDa, 9.941
Gene length, protein length 300 bp, 100 aa
Immediate neighbours sbcC, gerPF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YisB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YisB expression.png















Categories containing this gene/protein

proteins of unknown function

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU10660

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Miriam Pediaditakis, Miriam Kaufenstein, Peter L Graumann
Bacillus subtilis hlpB encodes a conserved stand-alone HNH nuclease-like protein that is essential for viability unless the hlpB deletion is accompanied by the deletion of genes encoding the AddAB DNA repair complex.
J Bacteriol: 2012, 194(22);6184-94
[PubMed:22984257] [WorldCat.org] [DOI] (I p)

Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146] [WorldCat.org] [DOI] (P p)