Epr

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  • Description: minor extracellular serine protease, involved in control of swarming motility PubMed

Gene name epr
Synonyms ipa-15r
Essential no
Product minor extracellular serine protease
Function protein degradation
Gene expression levels in SubtiExpress: epr
MW, pI 69 kDa, 9.875
Gene length, protein length 1935 bp, 645 aa
Immediate neighbours ywbA, sacX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Epr context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Epr expression.png
























Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, proteolysis, motility and chemotaxis

This gene is a member of the following regulons

DegU regulon, ScoC regulon, SigD regulon, SinR regulon

The gene

Basic information

  • Locus tag: BSU38400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: peptidase S8 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Original publications

Monica Gupta, Kestur Krishnamurthy Rao
Epr plays a key role in DegU-mediated swarming motility of Bacillus subtilis.
FEMS Microbiol Lett: 2009, 295(2);187-94
[PubMed:19416356] [WorldCat.org] [DOI] (I p)

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)

Prashant Kodgire, Madhulika Dixit, K Krishnamurthy Rao
ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis.
J Bacteriol: 2006, 188(17);6425-8
[PubMed:16923912] [WorldCat.org] [DOI] (P p)

Madhulika Dixit, Charuta S Murudkar, K Krishnamurthy Rao
Epr is transcribed from a final sigma(D) promoter and is involved in swarming of Bacillus subtilis.
J Bacteriol: 2002, 184(2);596-9
[PubMed:11751842] [WorldCat.org] [DOI] (P p)

A Sloma, A Ally, D Ally, J Pero
Gene encoding a minor extracellular protease in Bacillus subtilis.
J Bacteriol: 1988, 170(12);5557-63
[PubMed:3142851] [WorldCat.org] [DOI] (P p)